DNA DAMAGE RESPONSE

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DNA damage and replication stress play a major role in disease and are a hallmark of cancer. To maintain genome integrity and support normal functions, cells have evolved an intricate network of DNA damage repair and cell-cycle checkpoint pathways, collectively known as the DNA Damage Response (DDR). DDR processes are consistently altered in cancer and loss of genome integrity plays a causal role in cancer development. However, this unique tumor biology and DDR deficiencies can be leveraged therapeutically to effectively kill cancer cells while sparing normal tissues. Pharmacological control of DDR processes might be used to block tumor growth directly by hindering cell division and induce apoptosis, or indirectly by unleashing the immune system against tumor cells. Moreover, in recent years, DDR processes have been described to play roles in age-related diseases other than cancer, including trinucleotide repeat expansion syndromes, expanding the number of patients that may benefit from DDR-focused therapies. Pfizer scientists are eager to collaborate with leaders in the DDR space to develop novel, high-impact treatments for patients across therapeutic indications. Gaining control over DDR processes provides the opportunity to tackle high unmet medical needs from a differentiated angle improving the life of patients.

Pfizer is interested in partnering opportunities in the DNA Damage Response space to discover novel, life-changing therapies for patients.

Specific areas of interest include:

  • Increasing efficacy and safety of chemotherapies by combination with DDR modulators
  • Novel synthetic lethality opportunities to treat cancer
  • Approaches that unleash the immune system against tumors
  • Control of DDR processes to impact diseases other than cancer